在用于制备固体分散剂的制造技术方面的最新进展和专利
1Department of Pharmaceutical Sciences, Gurugram University, Gurugram, Haryana, India.
Recent advances in drug delivery and formulation
|November 20, 2025
概括
固体分散增强了药物生物可用性,用于溶解不良的药物. 现代制造和专利创新改善了药物输送,尽管稳定性和可扩展性仍然存在挑战.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
背景情况:
- 固体分散对于提高水溶性较差的药物的生物可用性和可溶性至关重要 (BCS II 和 IV 类).
- 制造业的进步和专利创新扩大了固体分散在制药配方中的应用.
研究的目的:
- 审查固体分散物的现代制造技术.
- 分析影响固体分散制备和应用的专利创新.
主要方法:
- 通过谷歌学者,PubMed,谷歌专利和科学直接进行全面的文献搜索.
- 分析现代制造技术,包括溶剂蒸发,喷雾干燥,热挤出,电和超临界流体方法.
- 审查像MeltrexTM和KinetiSol.这样的专利创新.
主要成果:
- 现代技术显著提高了固体分散的一致性,安全性,稳定性和可扩展性.
- 获得专利的创新扩大了固体分散在制药配方中的潜在用途.
- 尽管取得了进展,但在长期稳定性,再结晶和工艺可扩展性方面仍然存在挑战.
结论:
- 制造技术的持续创新和稳定性增强对于开发安全稳定的固体分散配方至关重要.
- 解决稳定性和可扩展性的挑战是充分实现固体分散的潜力的关键.
关键词:
这就是KinetiSolTM.固体的分散 固体的分散热挤出 热挤出patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent溶解度 溶解度 溶解度 溶解度喷雾干燥 喷雾干燥
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