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能有效合成具有超高药物载荷和pH响应持续释放性质的水友性毛半空分子打印聚合物微囊

Yan Zhou¹, Yanyan Mu¹, Huiqi Zhang¹

¹State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials (Ministry of Education), and College of Chemistry, Nankai University, Tianjin 300071, China.

ACS applied materials & interfaces

|November 20, 2025

概括

研究人员开发了新的半空分子印制聚合物 (MIP) 微囊,用于增强药物输送. 这些水友性毛的MIP提供超高的药物负载和pH响应释放,利用可逆添加碎片链转移 (RAFT) 聚合.

科学领域:

聚合物化学聚合物化学
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

开发先进的药物输送系统需要具有高负载能力和受控释放的材料.
分子印记聚合物 (MIP) 具有选择性,但在加载效率和受控释放动力学方面经常面临挑战.
水友性聚合物和受控聚合技术对于提高生物材料性能至关重要.

研究的目的:

为了合成明确的水友性毛半空的分子印记聚合物 (MIP) 微囊.
为了实现超高的药物负载能力和pH响应的持续释放.
为了展示一个多功能和高效的战略,创造先进的药物输送车辆.

主要方法:

使用单可逆添加-碎片化链转移 (RAFT) 沉聚合制备聚甲酸 (PMAA) 微球.
采用两步表面启动的RAFT聚合方式来接种一层propranolol-MIP和多2-乙基甲酸盐 (PHEMA) 刷子.
通过甲醇洗去除了PMAA核心的一部分,以创建半空洞结构.

主要成果:

成功合成了可调节厚度和蚀刻度的水友性毛半洞MIP微囊.
实现了超高的模板负载能力 (1637和1065μmol/g),明显超过了以前的MIP.
证明了快速模板结合动力学 (1分钟内平衡) 和pH响应的持续药物释放.

结论:

开发的战略提供了一种高效的方法,用于生产先进的水友性毛的半洞MIP微/纳米囊.
这些微囊表现出优越的药物加载和受控释放特性,使它们对药物输送非常有希望.
多功能RAFT聚合和核心蚀刻方法在生物分析应用中具有广泛的适用性.

关键词:

水友性聚合物刷子水友性聚合物刷有分子印记的聚合物.药物持续释放的pH响应性药物释放.半空洞的微囊中的微囊.超高的药物负载超高的药物负载

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