胎儿导管收缩,肺高血压和心房隔膜流动性:一项相关性研究
Paulo Zielinsky1,2, Polyanna Henriques1, Pedro Van Der Sand1
1Fetal Cardiology Unit, Instituto de Cardiologia/Fundação Universitária de Cardiologia-IC/FUC, Porto Alegre, RS, Brazil.
概括
在胎儿导管收缩 (DC) 的解决之后,隔膜原外流指数 (SPEI) 降低,与降低的肺动脉平均压力 (MPAP) 相对应. 这表明NSAID/多醇暴露逆转后胎儿心脏功能得到改善.
科学领域:
- 胎儿心脏病学 胎儿心脏病学
- 新生儿生理学 新生儿生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 母亲接触非类固醇抗炎药物 (NSAID) 或多 (PF) 可能导致胎儿导管收缩 (FDC).
- FDC与肺高血压和右心室过载有关,由增加的隔膜原外流指数 (SPEI) 表示.
研究的目的:
- 评估胎儿管道收缩 (DC) 解决后SPEI的变化.
- 评估SPEI与肺动脉平均压力 (MPAP) 在DC逆转后的相关性.
主要方法:
- 一项涉及52名患有FDC的孕妇的队列研究.
- 在DC逆转过程中和两周后测量了SPEI和MPAP.
- 使用Dabestani方程估计了MPAP.
主要成果:
- 在 DC 逆转之后,脉动性指数显著增加 (p < .001).
- 平均SPEI显著下降,从0.75 ± 0.13降至0.42 ± 0.12 (p < .001).
- 平均MPAP从70.33 ± 5.52 mmHg显著下降到53.27 ± 6.68 mmHg (p < .001),与SPEI有很强的相关性 (r = 0.690).
结论:
- 胎儿SPEI在管道收缩解决后降低.
- SPEI的降低与MPAP的降低有显著的相关性.
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