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Updated: Jan 10, 2026

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
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在SIMCYP中通过对临床人类PK数据的回顾性分析优化自下而上的PBPK模型开发

Julia A Schulz Pauly1, Alix F Leblanc2, Ekram A Chowdhury3

  • 1Quantitative, Translational & ADME Sciences (QTAS), AbbVie Inc., North Chicago, Illinois, USA.

Clinical and translational science
|November 20, 2025
PubMed
概括

优化生理学基础的药理动力学 (PBPK) 建模参数,包括胃肠道生理学和输送体表达,显著改善药物吸收预测. 这一战略提高了PBPK模型的准确性,用于药物发现和开发.

关键词:
胃肠道生理学胃肠道生理学这就是ISEF的意义.PBPKK PBPK 的意思是什么意思P-gp REF 是一个 REF.这是一个自下而上的自上.模型的性能模型的性能.

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Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
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Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
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Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
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Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
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Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
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Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
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