在撒哈拉以南非洲使用荷尔蒙避孕药的病理生理后果:一个范围审查
Marie Gorette Kampire1, Jean Claude Hakizimana2, Joseph Mucumbitsi3
1Department of Biochemistry, Adventist School of Medicine of East-Central Africa (ASOME), Kigali, Rwanda.
Open access journal of contraception
|November 20, 2025
概括
撒哈拉以南非洲 (SSA) 的荷尔蒙避孕药 (HC) 使用量正在上升,但与各种健康问题有关. 本次审查强调了需要在SSA进行综合咨询和监测,以确保安全的避孕措施和生殖健康.
科学领域:
- 生殖健康 生殖健康
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 在非洲人群中,荷尔蒙避孕药 (HC) 的安全性仍未得到充分研究.
- 在撒哈拉以南非洲 (SSA) 越来越多地使用HC用于预防怀孕.
- 报告的不良结果包括血液学,心脏代谢学,内分泌学,免疫学和心理学影响.
研究的目的:
- 总结最近关于HC在SSA中使用的病理生理后果的数据.
- 在SSA提供信息安全的避孕方法和生殖健康政策.
主要方法:
- 在2000-2025年发表在SSA.的研究范围审查.
- 在PubMed,非洲杂志在线,威利在线图书馆,谷歌学者中按照PRISMA-ScR指南进行了搜索.
- 包括实验室分析,调查,队列研究,RCT;数据按国家,设计,避孕药类型,不良结果划分.
主要成果:
- 分析了来自SSA的51项符合条件的研究.
- 血液学效应:更高的特征,降低了贫血风险.
- 心脏代谢影响:失脂症 (40-60%),高血压,体重增加 (1-3公斤/平方米BMI) 与DMPA和COCs.
- 其他影响:内分泌变化,增加感染脆弱性,免疫失调,微生物群变化,骨密度问题,抑郁症,出血不规则.
结论:
- 在SSA中使用HC与免疫,代谢,内分泌,血液学和心理方面的不良影响有关.
- 需要综合避孕咨询和临床监测并发症.
- 强调需要进行特定区域的研究,以确保安全的避孕措施的使用,并为SSA的生殖健康政策提供信息.
相关概念视频
Hormonal Regulation of the Menstrual Cycle
1.4K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
1.4K
Birth Control Methods
5.8K
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
5.8K
Hormonal Regulation
35.6K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
35.6K
Hormonal Regulation
47.7K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
47.7K
Hormonal Control of the Ovarian Cycle
6.4K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
6.4K
Hormonal Regulation of Blood Pressure
5.8K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
5.8K


