相关实验视频
Updated: Jan 10, 2026
05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
529
棕叶外瘤病变的棕叶外瘤病变:未被认可但重要的表现
1From the Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
Indian journal of dermatology
|November 20, 2025
概括
Palmoplantar pustulosis (PPP) 可以表现为手和脚以外的病变. 这项研究对日本患者的这些额外手掌盆病变进行了表征,揭示了不同的慢性和急性类型,具有不同的关节参与和分子途径.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 棕植物性 pustulosis (PPP) 通常会影响手掌和脚.
- 在PPP中,手掌外植物病变并不常见,但可以发生在身体的各种部位.
研究的目的:
- 在日本的PPP患者中,鉴定了 extrapalmoplantar病变的临床和组织病理特征.
- 为了研究这些病变背后的分子机制.
主要方法:
- 对23名日本患有PPP和外棕 ?? 植物性病变的患者进行了回顾性分析.
- 病变的分类为慢性 (状,红血) 和急性 (状) 类型.
- 组织病理学检查和分子分析 (S100,CCL20/CCR6,IL-36表达).
主要成果:
- 鉴定出了两种类型的手掌外病变:慢性 (n=15) 和急性 (n=8).
- 急性病变与较高频率的关节表现 (75% vs 13.3%) 相关,并由感染引发.
- 组织病理学显示,急性病变的特征与性牛皮相一致,而慢性病变的表皮变化没有Munro的微. 观察到S100警报蛋白,CCL20/CCR6和IL-36的升调.
结论:
- 在PPP中,手掌外植物病变可以分为不同的慢性和急性类型.
- 急性类型与感染和增加关节卷入有关.
- 通过CCL20/CCR6和IL-36通路激活警示素的机械刺激,可能涉及组织内存T细胞,有助于病变的发展.
相关概念视频
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
330
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
330
01:11Papillary Dermis
5.4K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.4K
01:25Endocarditis II: Clinical Features of Infective Endocarditis
381
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
381
01:30Peripheral Artery Disease I: Introduction
290
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
290
01:11Pulse Assessment Sites
2.4K
Pulse assessment sites are crucial in evaluating a patient's cardiovascular health. By assessing the pulsations of arteries at specific anatomical locations, healthcare professionals can gather valuable information about blood flow, heart rate, and peripheral circulation. Understanding these pulse assessment sites is essential for conducting comprehensive cardiovascular evaluations and monitoring patients' overall health. These sites are strategically chosen due to the accessibility and...
2.4K
01:27Assessment of the Cardiovascular System III: Palpation
974
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
974