阻塞性睡眠呼吸暂停和精神疾病的基于人口的风险
Chuan-Yi Kao1,2, Tsui-Hsein Huang3, Chuan-Hui Kao4
1Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Depression and anxiety
|November 20, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 显著增加患抑郁症和焦虑症的风险. 针对性查和管理对于高危人群至关重要,包括年轻人和超重患者.
科学领域:
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与神经和情绪失调有关.
- 在OSA中间歇性缺氧和睡眠碎片化可能会使个人易患精神疾病.
- 了解OSA对精神疾病风险的影响对于临床干预至关重要.
研究的目的:
- 调查阻塞性睡眠呼吸暂停 (OSA) 与患精神疾病的风险之间的联系.
- 量化OSA患者与非OSA个体之间的精神疾病风险差异.
主要方法:
- 使用TriNetX美国网络的非识别电子健康记录进行回顾性队列研究.
- 分析了7,079,095名个人 (18-65岁),其中368,125名OSA患者和4,396,092名非OSA患者在排除后.
- 倾向分数匹配 (PSM) 创建了平衡的队列 (每组360,708) 用Cox比例危险模型对新诊断的精神疾病进行8年风险评估.
主要成果:
- 在OSA患者中,抑郁症 (27.4%对15.8%) 和焦虑症 (37.4%对25.4%) 的8年累积概率显著提高.
- 在OSA患者中观察到双相情感障碍的风险增加 (HR: 1.885);精神分裂症的差异很小 (HR: 0.971).
- 亚组分析表明,年轻人和BMI较高的人群中精神疾病风险较高.
结论:
- 阻塞性睡眠呼吸暂停 (OSA) 是发展精神疾病,特别是抑郁症和焦虑症的重要危险因素.
- 这些发现强调了对OSA患者进行主动查和管理策略的必要性.
- 患有OSA的年轻人和超重的个体代表了一个特别高风险的人群,需要集中注意力.
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