通过皮肤传递药物输送系统的进步用于抗血栓治疗:系统性审查
Maria Augusta D Stersi1,2, Giovanna C Nader-Mota1, Erika Y Suzuki3
1Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
ACS pharmacology & translational science
|November 20, 2025
概括
通过皮肤递送药物为抗血栓治疗提供了一个有前途的替代方案,提高了药物的有效性和患者的坚持. 需要进一步的研究,以开发可扩展的跨皮肤抗血栓技术,用于临床使用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
背景情况:
- 血栓性疾病,包括动脉和静脉类型,是全球主要的健康问题,导致严重的发病率和死亡率.
- 抗血栓剂对于管理和预防血栓形成至关重要,但传统的输送方法面临挑战.
- 透皮药物递送系统为抗血栓治疗提供了一种新的方法,有可能提高生物可用性和患者遵守性.
研究的目的:
- 系统地审查当前关于透皮抗血栓配方的文献.
- 为了确定在通过皮肤应用中研究的抗血栓剂和输送系统的类型.
- 评估开发透皮抗血栓治疗的进展和挑战.
主要方法:
- 按照PRISMA指南进行了系统的文献审查,确定了25篇相关文章.
- 进行了数据库搜索,以收集关于透皮抗血栓剂配方的信息.
- 对正在进行或已完成的研究进行了临床试验注册表的搜索,但在这个特定领域没有发现任何研究.
主要成果:
- 审查重点关注的是肝素和乙酸的透皮配方,对直接口服抗凝剂的报道有限.
- 微针是研究最多的输送系统 (13项研究),其次是水凝 (5),聚合物贴片 (3) 和微/纳米乳液 (2).
- 没有发现正在进行或已完成的跨皮抗血栓治疗的临床试验.
结论:
- 通过皮肤的抗血栓配方显示出显著的治疗潜力,解决了传统施用途径的局限性.
- 正在探索微针和水凝等创新的输送系统,以改善药物输送.
- 需要进一步开发以创建临床可行,具有成本效益和可扩展的透皮抗血栓技术.
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