修改的老年人营养风险指数:一种高灵敏度标志物,在住院老年人中具有L形协会,用于医院住院老年人的肉症
Hua Wei1, Qin Huang1, Ming Liu1
1The Integrated Medical and Elderly Care Center, Chengdu Integrated TCM and Western Medicine Hospital, Chengdu, Sichuan, China.
Frontiers in nutrition
|November 20, 2025
概括
一个新的修改过的老年营养风险指数 (mGNRI) 有效地选老年医院患者的. 这种对炎症敏感的工具,包括C反应蛋白 (CRP) 和体重变化,显示出比传统指数更高的灵敏度.
科学领域:
- 老年医学 老年医学
- 营养科学 营养科学
- 炎症学 炎症学
背景情况:
- 在住院的老年人中,肉症查不足,因为忽视了炎症与营养之间的相互作用.
- 像GNRI和NRI这样的传统指数在这个人群中缺乏灵敏度.
- 开发了一种新的修改过的老年营养风险指数 (mGNRI),包括C反应蛋白 (CRP) 和体重变化.
研究的目的:
- 评估mGNRI在医院住院老年人中预测肉症的疗效.
- 将mGNRI的诊断性能与传统指数 (GNRI,NRI) 的诊断性能进行比较.
主要方法:
- 一项涉及153名住院患者的横截面研究,年龄为80.2±9.1年.
- 根据亚洲肉病工作组 (AWGS) 的标准 (肌肉质量,力量/功能) 进行肉病诊断.
- 分析包括限制立方线,多变量逻辑回归和ROC分析用于诊断性能比较.
主要成果:
- 麻症的患病率为24.2%. 在肉患者中,mGNRI显著降低 (48.1比56.8,p<0.001).
- mGNRI显示了与肉症风险的L形关联,在mGNRI<55 (OR = 8.40) 的关键值.
- 与GNRI/NRI相比,mGNRI (切断点55) 显示出更高的灵敏度 (80.4%) 和AUC (0.752).
结论:
- mGNRI是一种实用的,对炎症敏感的工具,用于在住院的老年人中查肉症.
- 确定的值 (mGNRI < 55) 提供了及时干预的目标.
- 将mGNRI整合到老年医学评估中可以改善有针对性的营养和炎症管理.
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