一种罕见的小囊下恶性淋巴瘤病例,需要紧急气管切除术
Teru Kamogashira1, Kazuka Arimoto1, Megumi Kishimoto1
1Department of Otolaryngology, JR Tokyo General Hospital, Tokyo, JPN.
Cureus
|November 20, 2025
概括
主要喉淋巴瘤是罕见的. 本案例研究详细介绍了一名患有无法分类的低级B细胞淋巴瘤的患者,该患者已成功接受化疗治疗,并在7年内实现完全反应.
科学领域:
- 在瘤学瘤学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 血液学 血液学 血液学
背景情况:
- 初级喉恶性淋巴瘤是一种非常罕见的临床实体.
- 该案涉及一名61岁的女性,患有声和呼吸障碍.
- 最初的症状对类固醇治疗没有反应,需要进行呼吸道干预.
研究的目的:
- 报告一种罕见的原发性喉淋巴瘤病例.
- 描述一种无法分类的低级B细胞淋巴瘤的诊断挑战和管理.
- 为了突出化疗在这种罕见疾病中的长期疗效.
主要方法:
- 临床表现和初始内镜评估.
- 呼吸道管理的新兴气管切除术.
- 组织病理学检查活检显示低级B细胞淋巴瘤 (可能是CD5阳性MALT淋巴瘤,无法分类).
- 用本达穆斯丁和修复药化学疗法的治疗.
主要成果:
- 渐进的小肠子病变导致气道阻塞.
- 组织学证实了一种无法分类的低级B细胞淋巴瘤.
- 患者在化疗后达到了持续7年的完整反应.
结论:
- 喉恶性淋巴瘤虽然很少见,但应在持续的喉症状的差异诊断中考虑.
- 用bendamustine和rituximab进行化疗可以对喉的未能分类的低级B细胞淋巴瘤非常有效.
- 涉及诊断和定制治疗的多学科方法对于管理罕见的瘤疾病至关重要.
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