dbCAN-HGM:不同人群的肠道微生物中的CAZyme基因集群
Yuchen Yan1, Revanth Sai Kumar Reddy Patel1, N R Siva Shanmugam1
1Nebraska Food for Health Center, Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE 68588, United States.
Nucleic acids research
|November 20, 2025
概括
dbCAN-HGM是一个新的数据库,详细介绍了人类肠道微生物群中的碳水化合物活性酶群 (CGC). 它将这些酶与饮食,疾病和人口联系起来,有助于微生物组研究.
科学领域:
- 微生物学 微生物学
- 生物信息学是一种生物信息学.
- 基因组学就是基因组学.
背景情况:
- 碳水化合物活性酶 (CAZymes) 对人类肠道微生物组 (HGM) 代谢至关重要.
- CAZyme基因集群 (CGC) 在肠道细菌中很常见,它们编码了降解甘氨酸的功能.
研究的目的:
- 开发dbCAN-HGM,这是一个对HGM CAZymes和CGCs的全面存储库.
- 为探索HGM基因组数据,酶功能及其关联提供一个用户友好的平台.
主要方法:
- 从6031个HGM基因组 (MAG) 中识别和注释了121,883个CGC.
- 根据多糖化物利用位置,将CGCs分为家族 (CGC-Fs),以推断基质.
- 整合各种饮食和疾病 (UC,克罗恩氏病) 的元基因组读取映射数据.
主要成果:
- dbCAN-HGM提供了详细的注释,包括CAZymes,载体,TF和蛋白质结构.
- 对CGC,CGC-F和相关元数据 (饮食,疾病,地理,分类学) 的交互可视化.
- 数据包括研究不足的种群,特别是来自非洲的种群,增强了全球微生物组的代表性.
结论:
- dbCAN-HGM 作为了解 HGM CAZyme 功能及其在人类健康中的作用的宝贵资源.
- 该数据库有助于研究HGM中的饮食-微生物-宿主相互作用和疾病机制.
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