Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

18.5K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.5K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

11.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.0K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

9.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

OLINK proteomics identifies inflammatory protein signatures associated with vascular cognitive impairment in diabetes.

Frontiers in immunology·2026
Same author

Brain endothelial cell-derived extracellular vesicles (c-BEEVs) as a promising biomarker for brain vascular pathology and cognitive decline.

Nature aging·2026
Same author

Pan-cancer Distant Metastasis Prediction Based on Graph Neural Network.

Interdisciplinary sciences, computational life sciences·2026
Same author

Editorial for Special Issue "Functional Genomics and Comparative Genomics Analysis in Plants, 3rd Edition".

Current issues in molecular biology·2026
Same author

CRESCENT: a deep learning framework with multi-scale attention for detecting recurrent copy number alterations.

Briefings in bioinformatics·2026
Same author

PETWB-REP: A Multi-Cancer Whole-Body FDG PET/CT Dataset with Corresponding Radiology Reports.

Scientific data·2026

相关实验视频

Updated: Jan 6, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

12.2K

CNAScope:泛癌复制号异常数据库,具有功能注释和交互式可视化.

Xikang Feng1,2, Jieyi Zheng1, Sisi Peng1

  • 1School of Software, Northwestern Polytechnical University, Xi'an 710072, China.

Nucleic acids research
|November 20, 2025
PubMed
概括

CNAScope是一个新的数据库,为癌症中的副本数异常 (CNA) 提供功能注释和可视化. 该资源有助于研究人员了解基因组多样性并加速癌症研究.

更多相关视频

Detection of Copy Number Alterations Using Single Cell Sequencing
09:45

Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

12.1K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.3K

相关实验视频

Last Updated: Jan 6, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

12.2K
Detection of Copy Number Alterations Using Single Cell Sequencing
09:45

Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

12.1K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.3K

科学领域:

  • 基因组学就是基因组学.
  • 在瘤学瘤学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 拷贝数异常 (CNA) 是基因组多样性和癌症瘤发生的关键驱动因素.
  • 现有的资源缺乏具体性,数据模式宽度,以及对经常性CNA的功能注释.

研究的目的:

  • 介绍CNAScope,一个针对策划和功能注释的体内CNA的综合数据库.
  • 为癌症基因组数据提供交互式可视化和注释工具.

主要方法:

  • 从810个数据集中策划了超过390万个CNA个人资料和390万个元数据.
  • 综合了来自77种癌症亚型的174464个样本的数据.
  • 开发了用于可视化,基因推断和CNA检测的交互工具.

主要成果:

  • CNAScope 收藏了来自不同癌症数据集的广泛的 CNA 档案和元数据.
  • 该数据库提供可下载的注释和在多个层面 (bin, gene, pathway) 的交互可视化.
  • 包括通过热图,基因树和嵌入图表探索数据的工具.

结论:

  • CNAScope是癌症研究的重要资源,提供了大量的CNA数据.
  • 促进对癌症的基因组多样性的深入分析和探索.
  • 授权研究人员上传和注释自己的CNA数据进行实时分析.