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相关概念视频

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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基于声流体的高频可控药物输送系统.

Rui You1, Shuting Pan2, Yuan Ning2

  • 1Fujian Key Laboratory of Agricultural Information Sensoring Technology, College of Mechanical and Electrical Engineering, Fujian Agriculture and Forestry University, Fujian Province, China. longbo2015@fafu.edu.cn.

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概括

这项研究引入了一种使用纳米通道和千兆赫兹声流体的新型声学药物输送系统. 这种可控制的系统调节了个性化药物的药物释放概况,为长期治疗提供了更高的精度.

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科学领域:

  • 生物医学工程 生物医学工程
  • 药物输送系统 药物输送系统
  • 声学 声学 在声学方面

背景情况:

  • 目前的药物输送系统难以满足个性化医疗的各种患者需求.
  • 可控制释放的特征对于有效的长期疗法至关重要.

研究的目的:

  • 开发一种具有可控制的零顺序和第一顺序释放配置文件的新型药物输送系统.
  • 调查声流体对药物释放调节的影响.

主要方法:

  • 利用水力动力学方法,将纳米通道与千兆赫兹 (GHz) 声流体学结合起来.
  • 采用有限元素方法模拟来分析声流和分子度.
  • 使用无线供电的植入式药物输送系统 (GADDS) 证明了FITC-dextran释放和*in vitro*第一阶段释放的调节.

主要成果:

  • 使用GHz声流体实现可控制的药物释放 (零级和一级).
  • 证明可调节的释放速率 (在低功率下缓慢,在高功率下增强).
  • 通过GADDS成功调节了*体外*的第一阶段释放.

结论:

  • 开发的系统为精确的药物输送提供了一个新的平台.
  • 这项技术通过实现量身定制的治疗配置文件,推进了个性化医疗.
  • 为下一代声学药物输送设备铺平了道路.