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Updated: Jul 2, 2026

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
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-药物联合体的PSMA触发阶段分离使得依赖性瘤抑制成为可能

Kai Han1, Jian Zhang1, Xiaolu Miao1

  • 1Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, P.R. China.

Angewandte Chemie (International ed. in English)
|November 20, 2025
PubMed
概括

一个新的类药物联合体 (PDC) 平台,LE-HOA,使用液体-液体相分离来增强瘤向和药物释放. 这种适应性系统可以提高药物稳定性和瘤抑制,为向癌症治疗提供了一种新的策略.

关键词:
液体与液体相隔离方法 液体与液体相隔离方法类药物合物是类药物合物.前列腺特异性膜抗原 (PSMA) 是一种抑制瘤的抑制作用依赖蛋白质酶是一种依赖蛋白质酶.

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