在输血依赖的沙拉西米亚患者中抗体的患病率
Neha Parashar1, Divya Gupta2, Tanvi Bhardwaj3
1Department of Clinical Pathology, Lok Nayak Hospital, New Delhi, India.
Annals of African medicine
|November 20, 2025
概括
在输血依赖的沙拉西米亚患者中,阿洛抗体的患病率为4.3%. 阴性Rh患者的合免疫发病率显著更高,突显了需要仔细进行血液匹配的需要.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 输血医学 输血医学
背景情况:
- thalassemia患者需要频繁的输血.
- 免疫是输血的一个重要并发症.
- 了解抗体发病率对于患者护理至关重要.
研究的目的:
- 为了确定输血依赖的血病患者中的抗体的患病率.
- 调查免疫接种与患者因素之间的关联.
主要方法:
- 对92名依赖输血的沙拉西米亚患者进行了回顾性研究.
- 间接抗球蛋白试验用于抗体查.
- 扩展面板用于抗体识别.
主要成果:
- 艾洛抗体的患病率为4.3% (95% CI:1.7%-10.6%).
- 在6名Rh (D) 阴性患者中,有2名Rh (D) 阴性患者发现了alloantibodies.
- Rh阴性表型与与免疫接种之间的显著关联 (P=0.0202).
结论:
- 阴性Rh (D) 类表型是thalassemia患者与免疫接种的危险因素.
- 在这个队列中,aloantibodies的患病率为4.3%.
- 在非特定情况下,可能需要进一步的研究来确定特定的alloantibodies.
相关概念视频
Blood Transfusion and Agglutination
14.0K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
14.0K
Blood Transfusion
2.1K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.1K
Blood Typing
2.3K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
2.3K
The ABO Blood Group
4.5K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
4.5K
Bone Marrow Sampling and Transplants
845
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
845
Rh Blood Group
2.7K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
2.7K


