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研究干眼病的研究结果参数:一个系统的文献审查

Viktoria Pai1, Doreen Schmidl1, Liudmyla Petric1

  • 1Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

Acta ophthalmologica
|November 20, 2025
PubMed
概括

开发有效的干眼病 (DED) 治疗方法是很困难的. 这次审查发现,诸如角膜染色和OSDI等常见终点往往无法显示治疗差异,这凸显了需要更好的临床试验措施的需要.

关键词:
干眼综合征 干眼综合征标志和症状 标志和症状系统性审查 系统性审查治疗结果治疗结果

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相关概念视频

Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...