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老年患者的型Dx乳腺癌检测:现实生活中的队列

Clément Grosnon¹, Lauren Seknazi¹, Djamel Ghebriou¹

¹Medical Oncology Department, Institut Universitaire de Cancérologie AP-HP Sorbonne Université, Tenon Hospital, Paris, France.

Cancer medicine

|November 20, 2025

概括

型DX测试有助于老年乳腺癌患者避免不必要的化疗. 基因组签名与瘤老年学评估相结合,可指导治疗决策,以获得更好的治疗结果.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
老年病的医生老年病的医生

背景情况:

型DX乳腺复发评分 (RS) 测试有助于在HR+,HER2-早期乳腺癌 (eBC) 中进行化疗决策.
关于其在老年患者群体中的有用性存在有限的数据.

研究的目的:

评估Oncotype DX测试在患有eBC的70岁以上患者中的有效性和实用性.
评估RS结果对该人口群的治疗决策和结果的影响.

主要方法:

365名70岁以上患有eBC的患者的前性队列研究 (2018-2023年).
在85名HR+/HER2患者进行瘤型DX测试;RS与瘤老年期评估一起进行分析.
基于RS组的无侵袭性疾病生存率 (IDFS) 和总生存率 (OS) 的统计分析.

主要成果:

在85名接受测试的患者中,有14名患者RS>25,与更高等级和更大的瘤相关.
在RS>25组中,50%接受了辅助化疗;在未接受治疗的患者中,5例复发中有4例发生.
对于RS>25 (p=0.0023),中位数IDFS显着较低,但OS没有显著差异.

结论:

型DX测试支持RS≤25患者的缓解,并在老年人中充当预后标志物.
在基因组测试之前,瘤老年病的评估对于指导老年乳腺癌患者的辅助治疗决策至关重要.

关键词:

型DX是DX的型型.辅助性化疗是一种辅助性化疗.乳腺癌乳腺癌乳腺癌年龄较大的患者.

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