在比较两个测量方法时,评估协议的信息标准方法
Charles Y Tan1, Yi Wang1, Ogert Fisniku2
1Data Sciences and Analytics, Research & Development, Pfizer Inc., New York, New York, USA.
Statistics in medicine
|November 20, 2025
概括
一种新的统计方法客观地比较使用信息标准的测量技术. 这种方法同时评估六个模型,为实验室和临床科学中的方法协议提供了一个明确的决策规则.
科学领域:
- 实验室和临床科学
- 生物统计学 生物统计学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 对比测量方法对于测试验证和监管合规性至关重要.
- 像布兰德-阿尔特曼图和德明回归这样的现有方法依赖于特定的模型假设.
- 需要一种更客观和数据驱动的方法来评估测量技术之间的一致性.
研究的目的:
- 引入一种新的统计方法来比较两个测量方法.
- 为评估协议提供客观,数据驱动的决策规则.
- 用现实数据评估拟议方法的性能.
主要方法:
- 建议采用一种基于信息标准的新型统计方法.
- 该方法同时对六种不同的统计模型进行数据评估.
- 该方法是使用以患者为中心的样本采集的试验比较数据来说明的.
主要成果:
- 建议的信息标准方法提供了一个客观而明确的决策规则.
- 它同时在多个模型中提供数据驱动的评估.
- 该方法被证明具有信息性和易于计算.
结论:
- 新的信息标准方法为实验室和临床环境中的方法比较提供了更好的替代方案.
- 这种综合方法提高了评估测量协议的客观性和清晰性.
- 它为测试验证和监管指导提供了一个强大的框架.
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