相关实验视频
Updated: Jan 10, 2026

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
2.4K
甲状腺激素缺乏会使疫苗病毒感染的结果恶化
Laura Notario1, Erika Guerrero-Espinosa2, Manuel Nistal3
1Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
Journal of virology
|November 20, 2025
概括
甲状腺功能低下症通过损害先天免疫力和脏淋巴细胞反应,使疫苗病毒肺部感染恶化. 替代甲状腺激素可能会对严重的病毒性肺部感染提供保护.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 病毒学 病毒学
背景情况:
- 疫苗病毒感染会导致肺部损伤和外周器官损伤.
- 甲状腺功能低下症是一种状况,甲状腺不能产生足够的甲状腺激素.
- 甲状腺激素在免疫系统功能中起作用.
研究的目的:
- 研究甲状腺功能低下症对小鼠疫苗病毒感染严重性的影响.
- 探索甲状腺功能低下小鼠增加敏感性的潜在机制.
- 确定甲状腺激素在抗病毒防御中的作用.
主要方法:
- 内注射疫苗病毒给甲状腺功能低下和甲状腺功能良好的小鼠.
- 评估疾病严重程度,病毒载荷和组织损伤.
- 脊髓免疫细胞群 (T和B淋巴细胞) 的评估.
- 对肺膜巨细胞群和功能进行分析.
- 膜巨细胞转移到甲状腺功能低下小鼠中.
- 将SRT1720 (Sirtuin 1激活剂) 给甲状腺功能良好的小鼠.
主要成果:
- 甲状腺功能低下症显著加剧了疫苗病毒感染,导致较高的疾病得分,增加的肺病毒载荷,以及更广泛的组织损伤.
- 甲状腺功能低下的小鼠表现出缺陷的脏免疫反应和受损的淋巴细胞放大.
- 甲状腺功能低下小鼠肺膜巨细胞的减少,有助于增加敏感性,因为巨细胞的转移减轻了症状.
- 疫苗病毒感染会降低甲状腺激素水平在非甲状腺小鼠 (非甲状腺疾病综合征).
- 施用SRT1720会使疫苗感染恶化,这表明甲状腺激素有保护作用.
结论:
- 甲状腺功能低下症通过受损的先天免疫力 (降低膜巨细胞) 和适应性免疫力 (缺陷的脏淋巴细胞反应) 加重了疫苗病毒感染的严重程度.
- 甲状腺激素似乎在病毒性肺部感染中起着保护作用.
- 涉及甲状腺激素替代的治疗策略可能有利于治疗严重的病毒性肺部感染.
相关概念视频
Vaccinations
51.2K
Overview
51.2K
Synthesis and Regulation of Thyroid Hormones
7.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.1K
Pulmonary Tuberculosis I
811
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
811
The Thyroid Gland
6.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.6K
Functions of Thyroid Hormones
4.9K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
4.9K
Myasthenia Gravis: Overview and Treatment
2.7K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.7K

