相关实验视频

Updated: Jan 10, 2026

Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface

Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface

Published on: July 21, 2016

齐克病毒感染通过激活PANoptosis引起胎盘炎症

Shuqing Zhang^1,2, Delin Chen³, Kexin Zhang⁴

¹School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

Journal of virology

|November 20, 2025

概括

在怀孕期间感染寨卡病毒 (ZIKV) 引发了胎盘炎症通过热囊细胞 PANoptosis. 抑制这种细胞死亡途径为对抗ZIKV相关的先天性疾病提供了潜在的治疗策略.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

孕妇感染寨卡病毒 (ZIKV) 可能导致先天性寨卡综合征 (CZS) 和其他婴儿神经疾病.
了解ZIKV对胎盘的影响对于预防CZS至关重要.
由ZIKV诱导的胎盘病变的确切机制尚不清楚.

研究的目的:

用小鼠模型研究ZIKV感染后胎盘的病理变化.
阐明 trofhoblast细胞死亡途径在ZIKV诱导的胎盘炎症中的作用.
为了确定ZIKV相关的胎盘疾病的潜在治疗点.

主要方法:

建立一个感染ZIKV的孕妇小鼠模型.
检查胎盘病理和细胞对ZIKV感染的反应.
对参与细胞死亡和炎症的分子通路的分析,包括RIG-I,ASC,NLRP3和RIPK1.

主要成果:

寨卡病毒感染诱导严重的胎盘炎症.
热囊细胞泛灭被确定为ZIKV诱导的胎盘损伤的一个关键机制.
齐克病毒通过RIG-I,ASC,NLRP3,caspase-1,caspase-8和RIPK1.1激活了PANoptosome复合体.
联合抑制Z-VAD-FMK与GSK872或RIG012抑制ZIKV诱导的细胞死亡和炎症.

结论:

齐克病毒感染会通过激活多细胞PANOPTOSIS引起严重的胎盘炎症.
这些发现揭示了ZIKV病变的新型机制.
向PANoptosis为ZIKV相关并发症提供了潜在的治疗途径.

关键词:

这就是PANoptosis.在ZIKVV,你会发现.胎盘炎症胎盘炎症热囊细胞细胞的细胞.

更多相关视频

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

相关概念视频

Immune Response Against Viral Pathogens

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...