胸膜刺激诱导了中网络连接和兴奋能力的变化
Nicholas M Gregg1, Gabriela Ojeda Valencia2, Tereza Pridalova1
1Department of Neurology, Mayo Clinic, Rochester, MN.
Annals of neurology
|November 20, 2025
概括
深度大脑刺激 (DBS) 和大脑刺激唤起潜力 (BSEPs) 在sEEG地图网络期间. 较长的DBS试验调节了网络刺激性,而较短的试验减少了活动,推进了生物标志物告知的神经调节.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 生物标志物 生物标志物
背景情况:
- 深度大脑刺激 (DBS) 效应发生在各种时间尺度上,使治疗优化复杂化.
- 大脑刺激唤起的潜能 (BSEPs) 提供了对网络刺激性和连接性的见解.
研究的目的:
- 在sEEG期间整合BSEP和DBS试验,以绘制扣押网络的地图.
- 调节网络动态并监测生物标志物告知中神经调节的兴奋性.
主要方法:
- 对接受临床EEG脑电图治疗的10名患者进行了回顾性分析.
- 高频体DBS试验与刺激前后获得BSEP.
- 自动追踪间接性形排泄的自动追踪.
主要成果:
- 基线BSEPs确定了不同的thalamic子领域网络参与模式.
- DBS>1.5小时降低了BSEP振幅,与连接强度相关.
- 较短的DBS试验在连接的网络中抑制了间接性形释放率.
结论:
- 在sEEG期间的BSEP和DBS试验提供了新的网络生物标志物.
- 这种方法可以评估跨时间尺度的大规模网络调制.
- 推进用于治疗的生物标志物告知的神经调节策略.
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