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对超声波增强剂的严重过敏药物反应导致心脏性休克
Alexander Levy1, Jason Feinman1, Matthew Cagliostro1
1The Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
JACC. Case reports
|November 20, 2025
概括
对超声波增强剂 (UEA) 的严重过敏反应越来越多. 一个罕见的病例显示了对Lumason的过敏反应引起心脏性休克,突出显示了选择性UEA使用的必要性.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 过敏和免疫学 过敏和免疫学
背景情况:
- 超声波增强剂 (UEA) 提高了心声回声诊断的诊断质量.
- 虽然很少见,但已经记录了对UEA的严重过敏反应.
- 与历史数据相比,当代观察研究报告了更高的不良药物反应 (ADR) 率.
研究的目的:
- 报告一种罕见的严重过敏反应对UEA导致心脏性休克的罕见病例.
- 突出了对UEAs的ADRs日益增长的流行.
- 强调从过敏反应到应力心肌病和心脏性休克的潜在过渡.
主要方法:
- 一个39岁的患有心力衰竭的妇女的病例报告经历了对UEA的严重过敏反应.
- 序列回声心脏图,以评估左心室喷射率 (LVEF) 的变化.
- 对UEAs的ADR进行文献综述,比较Lumason和Definity.
主要成果:
- 该患者在UEA给药后发生了 Society for Cardiovascular Angiography & Interventions D期心脏性休克.
- 在活动期间,LVEF从45%下降到20%,在释放之前恢复到35%.
- 与Lumason相比,在最近的研究中观察到较高的ADR率与Definity相比.
结论:
- 从Lumason的过敏反应中继的心脏性休克以前没有被描述过.
- 患有潜在心肌病并对UEA产生不良反应的患者需要密切监测,因为有应激心肌病和心脏性休克的风险.
- 由于可能出现显著的副作用,UEA应选择性地使用.
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