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在肝素固定中使用低速度旋转改善了管状细胞血管支架的抗血栓性

Hoang Minh Lam^1,2,3, Nho Thuan Nguyen^1,2,3, My Thi Ngoc Nguyen^1,2,3

¹Laboratory of Tissue Engineering and Biomedical Materials, University of Science, 227 Nguyen Van Cu Street, Cho Quan Ward, Ho Chi Minh City, Vietnam.

Tissue engineering and regenerative medicine

|November 20, 2025

概括

这项研究通过使用滚筒辅助层次 (LbL) 方法来固定肝素来改善无细胞血管移植. 增强的支架显示减少了血栓形成和改善了血红相容性,以改善血管再生.

科学领域:

生物材料科学生物材料科学
血管组织工程血管组织工程
表面化学表面化学

背景情况:

无细胞血管支架缺乏抗凝性质,增加了血栓的风险.
血栓生成性阻碍了小直径血管移植的临床使用.

研究的目的:

为了提高无细胞血管支架的血红相容性.
用滚筒辅助层层 (LbL) 技术研究肝素固定.

主要方法:

在脱细胞化的支架上通过使用基于DHI的链接器的静电相互作用将肝素固定.
使用滚筒管系统用于低速旋转的LbL组件.
通过1,4,7,10,13个沉积周期优化肝素加载,以持续释放.

主要成果:

在28天的时间内实现持续的氨酸释放,并具有长时间的抗凝剂活性.
显著减少了血栓形成,并表现出最小的溶血活性.
促进内皮细胞粘附,这对血管完整性和通透性至关重要.

结论:

滚筒辅助的LbL肝素化是有效的改善血管移植的血液兼容性.
这种可扩展的策略解决了血管组织工程中的血栓性.
该方法对生物工程血管结构的临床翻译有前途.

关键词:

抗凝剂是一种抗凝剂.肝素是一种肝素.一层一层的层次.小直径的血管移植.血栓形成的原因之一是血栓形成.

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