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Updated: Jan 10, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
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来自N端PAC1R替代拼接的修改联体选择性的结构基础

Jessica J Lu1,2, Giuseppe Deganutti3, Miaomiao Li1,2

  • 1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.

Proceedings of the National Academy of Sciences of the United States of America
|November 20, 2025
PubMed
概括

pituitary adenyl cyclase-activating polypeptide 1 receptor (PAC1R) 的短变体 (PAC1sR) 由于其细胞外域 (ECD) 的结构差异与零变体 (PAC1nR) 相比,显示出增强的VIP活性. 这种拼接会影响连接体结合和G蛋白信号传递.

关键词:
低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.连接物选择性 连接物选择性pituitary腺酸环酶激活多1受体拼接的变种 拼接的变种

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