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1型糖尿病患者错过一顿饭的缓解策略,使用MinimedTM 780G系统进行缓解
Bruno A Grassi1, María Teresa Onetto1, Germán Mora1
1Departamento de Nutrición, Diabetes y Metabolismo, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Diabetes technology & therapeutics
|November 20, 2025
概括
对于使用MiniMedTM 780G系统的1型糖尿病 (T1D) 患者来说,用于血糖控制的最佳方法是预食玻尿酸. 延迟的校正玻尿酸可显著改善结果,如果一个饭碗玻尿酸错过了.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 医疗器械 医疗器械
背景情况:
- 餐后血糖控制对1型糖尿病 (T1D) 患者来说是一项挑战,即使使用像MiniMedTM 780G (MM780G) 这样的先进混合闭环 (AHCL) 系统.
- 错过的饮食时间胰岛素胆固醇经常发生,并对T1D管理中的血糖控制产生负面影响.
- 评估错过螺栓的策略对于优化AHCL系统性能至关重要.
研究的目的:
- 评估使用MM780G系统在T1D的成年人中错过的餐 boluses 的正确的食后 bolus 策略.
- 为了比较食前玻尿酸注射与无玻尿酸注射与延迟校正玻尿酸注射在食后血糖控制的疗效.
- 确定不同玻尿酸策略对时间在范围 (TIR) 和时间在狭窄范围 (TITR) 的影响.
主要方法:
- 一项前性,开放性,现实研究,涉及32名T1D成年人,使用MM780G系统.
- 三个标准化的饮食场景 (大约. 60克碳水化合物) 进行了测试:餐前玻尿酸注射 (对照),没有玻尿酸注射,以及延迟玻尿酸注射 (50%碳水化合物含量,餐后60分钟).
- 主要结局是食后4小时的TIR (70-180毫克/分升);次要结局包括TITR (70-140毫克/分升) 和低血糖事件.
主要成果:
- 前期玻尿酸策略产生了最高的TIR (85.5%),明显优于没有玻尿酸 (52.3%) 和延迟玻尿酸 (63.5%).
- 与没有玻尿酸 (E2) 相比,延迟校正玻尿酸 (E3) 显著改善了TIR和TITR,而低血糖症没有增加.
- 当没有采取任何纠正措施时,MM780G系统通过自动基础和自动校正功能提供了错过的螺栓的部分补偿.
结论:
- 在使用MM780G系统的T1D患者中,预先注射胰岛素仍然是食后血糖控制的最佳策略.
- 延迟校正玻尿酸 (50%碳水化合物含量,饭后1小时) 是改善血糖控制的有效策略,当饭碗玻尿酸被遗漏时.
- MM780G系统显示出某种程度的自动补偿错过的螺栓,减轻严重的血糖偏差.
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