在中国族人群中,Helicobacter pylori的抗菌耐药性
Jinzhi Zhang1,2, Ying Wang1, Liyu Chen1,2
1Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.
The Journal of infectious diseases
|November 20, 2025
概括
杆菌的抗生素耐药性是一个主要的挑战. 这项研究在中国族群中发现了对甲尼达和利芬素的高耐药性,表明需要量身定制的治疗策略.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
背景情况:
- 抗生素耐药性复杂化了Helicobacter pylori的根除工作.
- 了解特定种族群体的抵抗模式对于有效治疗至关重要.
研究的目的:
- 确定来自中国族人口的H. pylori菌株抗生素耐药性概况.
- 在这个队列中确定与抗菌素耐药性相关的因素.
主要方法:
- H. pylori从501名患者的胃活检中分离出来.
- 对七种抗生素进行了抗菌感应性测试 (AST).
- 后勤回归分析确定了与阻力相关的因素.
主要成果:
- 慢性胃缩的发病率很高 (75.6%).
- 总体耐药性率:阿莫西西林 (0.0%),四环素 (0.4%),克拉里斯罗米辛 (22.9%),美特罗尼达 (86.3%),莱沃弗洛克萨辛 (39.7%),里芬皮辛 (52.7%),弗拉佐利 (0.0%).
- 在32.1%的菌株中发现了多药耐药性;年龄和女性性别与耐药性有关.
结论:
- 对克拉利米辛,美特罗尼达和莱沃弗洛克萨辛的高耐药性需要避免经验性使用.
- 氨基西林,四环素和富拉索利的耐药性较低,表明有效治疗方案的潜力.
- 慢性胃缩的患病率凸显了H. pylori查和根除对于预防胃癌的重要性.
相关概念视频
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
1.1K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.1K
01:30Development of Antibiotic Resistance
1.2K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.2K
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
513
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
513
01:30Peptic Ulcer Disease I: Introduction
719
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
719