患有支气管肺功能障碍的婴儿的结局
Dwi Kisworo Setyowireni1, Roni Naning1, Rina Triasih1
1Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia.
PloS one
|November 20, 2025
概括
患有支气管肺功能障碍 (BPD) 的婴儿面临高死亡风险,近一半的婴儿在七个月内死亡. 过早生育 (月经后年龄<28周) 显著增加了这种风险,而机械通风可以提供保护.
科学领域:
- 新生儿科学 新生儿科学
- 儿科肺病学 儿科肺病学
- 公共卫生 公共卫生
背景情况:
- 支气管肺功能障碍 (BPD) 是婴儿最常见的慢性肺部疾病.
- 印度尼西亚的雅加达为研究BPD结果提供了特定的人口.
研究的目的:
- 评估被诊断患有BPD的婴儿在Yogyakarta的结果.
- 确定患有BPD的婴儿死亡率的预测因素.
主要方法:
- 对患有BPD的婴儿进行回顾性队列研究 (2015年1月至2020年12月).
- 医疗记录审查和临床评估,包括幸存者的心声回声图.
- 多变量逻辑回归分析以确定死亡率预测因素.
主要成果:
- 在8,490名新生儿中,1.2%患有BPD;在85名完整数据的婴儿中,48.2%在7个月内死亡.
- 新生儿败血症和先天性心脏病是常见的并发症.
- 月经后年龄<28周 (OR5.27) 和机械通风 (OR0.26) 是死亡率的独立预测因素.
结论:
- 近一半患有BPD的婴儿在七个月内死亡.
- 月经后年龄小于28周是死亡的重要风险因素.
- 机械通风在这个群体中显示出对死亡率的保护作用.
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