在社区居住的老年人中创伤性脑损伤和抑郁症状:前性队列研究
Holly Elser1, Rogan G Magee1, Sabrina Abbruzzese1
1Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia.
Neurology
|November 20, 2025
概括
具有创伤性脑损伤 (TBI) 史的老年人面临更高的抑郁症状和抗抑郁药物的使用风险. 这些发现凸显了对这一群体进行主动查和治疗的需要.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 情绪症状是创伤性脑损伤 (TBI) 的已知短期影响.
- 有限的研究存在于老年人,社区居住的个人TBI的抑郁症状,先前的研究侧重于较短的随访期.
研究的目的:
- 研究老年人的创伤性脑损伤 (TBI) 和抑郁症状之间的关联.
- 检查TBI对心理健康结果的长期影响,特别是抑郁症状和抗抑郁药的使用.
主要方法:
- 对社区动脉样硬化风险研究的分析,这是美国社区成年人的前性队列.
- 通过自我报告和ICD代码识别的创伤性脑损伤 (TBI);从2011-2019年评估的抑郁症状和抗抑郁药的使用.
- 用于估计TBI与抑郁症状和抗抑郁药物处方相关的风险比率的概括估计方程 (GEE),对共变量进行调整.
主要成果:
- 包括6,607名参与者 (平均年龄75岁);32.0%的人有TBI病史.
- 创伤与抑郁症状 (RR 1.59) 和抗抑郁药物使用 (RR 1.32) 的风险显著增加有关.
- 这些关联在根据年龄,性别,种族和健康特征定义的子组中保持强,无论TBI的严重程度或频率如何.
结论:
- 在老年社区成年人中,创伤性脑损伤 (TBI) 和抑郁症状/抗抑郁药的使用之间存在强烈和持久的联系.
- 这些发现强调了普遍查和及时治疗TBI病史的老年人抑郁症状的重要性.
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