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患有多发性硬化症 (MS) 的患者在开始使用Ocrelizumb之前进行感染查:基于伊朗MS - 传染病小组代表修改的Delphi共识的简要临床建议
Sepideh Paybast1, Marzie Abutorabi-Zarchi2, Fereshteh Ashtari3
1Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Iran.
Multiple sclerosis and related disorders
|November 20, 2025
概括
在多发性硬化症患者中,ocrelizumab可以增加感染风险. 这一共识为伊朗医生提供了67条基于证据的建议,用于查,预防和在治疗ocrelizumab之前和治疗期间管理感染.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 奥克雷利祖马布是一种用于多发性硬化症 (MS) 的B细胞耗尽疗法.
- 科学文献强调,在患有多发性硬化症 (PwMS) 的患者中,与ocrelizumab治疗相关的感染风险增加.
- 伊朗医生需要指导来管理这些感染风险.
研究的目的:
- 制定基于证据的建议,用于查和管理感染在PwMS启动ocrelizumab治疗.
- 协助伊朗医疗保健专业人员就与ocrelizumab相关的感染风险做出临床决策.
主要方法:
- 使用了经过修改的德尔菲共识流程.
- 一个多学科专家小组 (MS专家,传染病专家,胃肠道专家) 参加了会议.
- 根据科学文献和临床相关性制定了建议.
主要成果:
- 专家小组制定了67份共识声明.
- 这些建议包括查,预防,监测和早期治疗感染.
- 针对的特定感染包括结核病,VZV,HBV,HCV,HIV和二次性低血糖球蛋白血症.
结论:
- 该共识提供了一个全面的框架,用于在PwMS中管理与ocrelizumab相关的感染风险.
- 这些建议旨在优化患者安全和治疗结果.
- 这些指导方针支持伊朗医生在对ocrelizumab治疗方面做出明智决策.
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