在小儿自身免疫性脑炎和急性扩散性脑膜炎中MRI皮层厚度
Charly H A Billaud1, Daniel Griffiths-King2, Evangeline Wassmer3
1College of Health & Life Sciences & Aston Institute of Health and Neurodevelopment, Aston University, Birmingham, UK; Psychology, School of Social Sciences, Nanyang Technological University, Singapore.
概括
患有自身免疫性脑炎的儿童可能会经历长期皮质稀薄. 这项研究发现,在疾病发病多年后,特定的大脑区域的灰质厚度减少,突出显示了潜在的慢性神经炎症影响.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 儿科神经学 儿科神经学
背景情况:
- 儿科自身免疫性脑炎和急性传播性脑炎 (ADEM) 是神经炎症性疾病.
- 这些情况可能导致急性MRI异常,并且越来越多地与长期的大脑体积减少有关.
研究的目的:
- 调查诊断为自身免疫性脑炎 (包括抗NMDA脑炎和ADEM) 的儿童皮层厚度的长期变化.
- 确定灰质厚度下降是否存在于全脑皮层厚度,极和轨道前皮层疾病发病后的几年.
主要方法:
- 招募了一组具有自身免疫性脑炎病史 (诊断后至少两年) 的儿童和一组典型发育儿童的对照组.
- 从T1wMRI扫描中测量皮质厚度,使用Freesurfer进行全脑分析和特定感兴趣的区域.
主要成果:
- 对12名患有自身免疫性脑炎的儿童和48名对照儿童的MRI分析显示,在一个包含左上回和左上叶叶部分的集群中,皮层厚度明显较低.
- 对特定感兴趣区域的皮质厚度没有发现显著的多变量效应,尽管在自身免疫性脑炎组中,单变量效应表明左下轨道前额厚度.
结论:
- 患有自身免疫性脑炎的儿童可能会经历局部皮质稀薄作为疾病的长期后果.
- 这些发现表明,在儿科神经炎症性疾病后,持续的结构性大脑变化.
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