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Updated: Jan 10, 2026

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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Published on: February 28, 2021

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HSP90缓冲了BRCA1中的有害遗传变异

Brant Gracia1, Xing-Han Zhang2, Patricia Montes1

  • 1Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Molecular cell
|November 20, 2025
PubMed
概括

热冲击蛋白90 (HSP90) 稳定了突变的BRCA1蛋白,赋予了抗癌疗法的能力. 抑制HSP90可以克服这种抗性,揭示了BRCA1相关癌症的新治疗脆弱性.

关键词:
这就是BRCA1的原因.在HSP90中,它是HSP90的.抑制HSP90的发生抑制PARP的抑制作用乳腺癌 乳腺癌 乳腺癌突变缓冲区是一个突变缓冲区.聚疗法是一种多疗法.蛋白质折叠 蛋白质的折叠结构突变 结构突变合成杀伤性 合成杀伤性

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