石榴 (Punica granatum) 作为类风湿性疾病的辅助疗法:系统性审查
Jozélio Freire de Carvalho1, Elizabeth Hautz2
1Núcleo de Pesquisa em Doenças Crônicas não Transmissíveis (NUPEC), School of Nutrition from the Federal University of Bahia, Salvador, Bahia, Brazil.
Clinical nutrition ESPEN
|November 20, 2025
概括
石榴补充剂显示,通过减少炎症和氧化应激,有潜力治疗类风湿性疾病,如类风湿性关节炎和骨关节炎. 需要进一步的高质量研究来证实其有效性和安全性.
科学领域:
- 风湿病学和营养科学
- 自然产品研究自然产品研究
背景情况:
- 风湿性疾病 (RA,OA) 涉及慢性炎症和氧化应激,导致关节损伤.
- 传统治疗可能有局限性,对补充疗法的兴趣越来越大.
- 石榴 (Punica granatum) 由于其丰富的多含量,具有抗炎和抗氧化特性.
研究的目的:
- 系统地审查临床和临床前证据,以补充石榴用于类风湿性疾病.
主要方法:
- 搜索了主要的数据库 (PubMed,Scopus等) 在2024年12月之前.
- 包括RCT,观察性研究和RA,OA和自身免疫性风湿性疾病的临床前模型.
- 使用已有的工具评估研究质量 (RoB 2,NOS,AMSTAR 2,GRADE).
主要成果:
- 七项研究 (5项临床,1项临床前,1项体外) 符合标准.
- 石榴降低了炎症标志物 (DAS28,ESR,CRP,IL-6,TNF-α) 和改善了RA和OA的疼痛/功能评分 (WOMAC,KOOS,VAS).
- 临床前数据显示抑制炎症途径 (NF-κB,MAPK) 和软骨保护;在临床试验中一般耐受良好.
结论:
- 石榴在风湿性疾病中表现出有希望的抗炎和抗氧化作用.
- 由于研究的局限性,证据质量低至非常低.
- 在临床推之前,需要进行更大,高质量的RCT来确认疗效和安全性.
关键词:
抗氧化剂 抗氧化剂是一种抗氧化剂.补充疗法是一种补充疗法.炎症 炎症是一种炎症.骨关节炎是一种骨关节炎.聚醇是一种多醇.石榴果 石榴果是一种这是一种Punica granatum.类风湿性疾病 类风湿性疾病类风湿性关节炎 类风湿性关节炎 类风湿性关节炎安全的安全的安全的安全的安全.系统性审查 系统性审查更多相关视频
04:47Author Spotlight: Evaluating Traditional Chinese Therapy for Ankylosing Spondylitis in Mice
Published on: October 27, 2023
1.7K
07:36Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
1.9K
相关概念视频
01:21Rheumatic Heart Disease III: Medical Management
268
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
268
01:23Rheumatic Heart Disease I: Introduction
415
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
415
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
460
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
460
01:17Pericarditis III: Medical Management
290
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
290
01:20Rheumatic Heart Disease IV: Nursing Management
252
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
252
01:29Inflammatory Bowel Disease IV: Pharmacological Management
452
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
452