培养负细菌:在细菌病原体优先排序中的一个盲点
Carl Boodman1, Cansu Cimen2, Nitin Gupta3
1Division of Infectious Diseases, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium; Department of Medical Sciences, University of Antwerp, Antwerp, Belgium.
概括
培养负菌 (CNB) 是低收入国家发烧的常见原因,但经常被忽视. 这篇综述强调了诊断方面的挑战和偏见,这些偏见有助于全球卫生领域的诊断不足和忽视.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 全球健康 全球健康
背景情况:
- 培养负性细菌 (CNB) 如巴顿氏菌,氏菌,瑞克菌,东方菌和勒普托斯皮拉菌会导致严重的发烧性疾病,特别是在低收入和中等收入国家 (LMICs).
- 标准的诊断方法往往无法检测这些病原体,导致低诊断和低估它们对公共健康的影响.
- 在LMICs的诊断基础设施有限和高病原体多样性加剧了这个问题.
研究的目的:
- 评估当前的传染病指导方针,以在CNB的背景下识别和优先考虑病原体.
- 识别诊断局限性和认知偏见,这些偏见有助于忽视 CNB 感染.
- 强调需要在全球卫生议程中加强对CNB的认可和研究投资.
主要方法:
- 对现有的传染病指南进行叙述性审查.
- 将指南标准应用于中国央行,以评估合适性和识别差距.
- 讨论诊断挑战,临床医生偏见和流行病学数据碎片化.
主要成果:
- 现有的框架往往未能充分纳入或优先考虑CNB检测.
- 诊断的局限性和临床医生的偏见显著阻碍了CNB的识别.
- 在LMICs中,CNB的不成比例负担是由碎片化的数据和有限的研究加剧的.
结论:
- CNB是一种被忽视的病原体群,尽管它们在全球范围内对发烧性疾病产生重大影响,特别是在LMICs.
- 系统性低诊断源于技术,认知和系统因素的结合.
- 解决对CNB的忽视需要修订诊断和优先级框架,改善基础设施,并增加研究投资.
相关概念视频
01:31Defense Against Bacterial Pathogens
2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K
00:57Antibiotic Selection
59.3K
Overview
59.3K
01:20Applications of Molecular Taxonomy
489
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
489
01:26Urine Studies II: Urine Culture and Sensitivity Test
776
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
776
01:28Biological Methods for Microbial Control
763
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
763
01:30Development of Antibiotic Resistance
1.2K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.2K