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骨关节炎的适应性免疫:调节性T细胞向治疗的机制和机会

Xueyou Zhang¹, Mingde Cao¹, Bruma Sai-Chuen Fu¹

¹Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; Center for Neuromusculoskeletal Restorative Medicine (CNRM), The Chinese University of Hong Kong, Hong Kong, China.

Pharmacological research

|November 20, 2025

概括

适应性免疫,特别是调节性T (Treg) 细胞,在骨关节炎 (OA) 发病过程中起着关键作用. 对突Treg细胞功能的进一步研究对于开发新的疾病修饰性OA疗法至关重要.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
细胞生物学细胞生物学

背景情况:

骨关节炎 (OA) 是一种普遍的退行性关节疾病,影响全球超过5亿人.
目前的OA疗法缺乏疾病修饰能力,凸显了需要新型治疗策略的需要.
慢性突关节炎是OA关节损伤的关键驱动因素,但准先天免疫路径取得了有限的成功.

研究的目的:

审查适应性免疫反应对OA病变发生的贡献.
强调OA中的突调节T细胞 (Treg) 的作用和治疗潜力.
确定有关OA关节Treg细胞功能的关键问题.

主要方法:

对OA适应性免疫的临床,实验和遗传研究的审查.
对研究突T和B淋巴细胞,自身抗体和抗原呈现的研究进行分析.
对突Treg细胞表型和临床观察数据的检查,包括孟德尔随机化分析.

主要成果:

甲状腺关节显示了抗原经验T和B淋巴细胞的透,有克隆扩张和自身抗体生成的证据.
在整个骨髓炎疾病进展过程中,共结Treg细胞存在,表现出组织居民和激活特征.
临床数据表明CD25+ Treg细胞在OA中起着保护作用.

结论:

适应性免疫活动显著促进了OA的发病.
在OA关节中,总是发现交叉体Treg细胞,但它们的确切免疫功能需要进一步阐明.
定义Treg细胞抗原特异性,抑制能力和功能稳定性对于开发基于免疫的OA疗法至关重要.

关键词:

适应性免疫是一种适应性免疫.抗原是一种抗原.免疫治疗是一种免疫疗法.炎症炎症是一种炎症.骨关节炎是一种骨关节炎.在T ((reg) 细胞中.

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