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Updated: Jan 10, 2026

A Flow Cytometry-based Assay for Measuring Mitochondrial Membrane Potential in Cardiac Myocytes After Hypoxia/Reoxygenation
07:14

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斯芬哥辛-1-酸盐通过线粒体的活性氧生产激活了室腔肌细胞中的ICl,swell

Frank J Raucci1, Adolfo G Mauro2, Edward J Lesnefsky3

  • 1Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA; Division of Pediatric Cardiology, Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University Health System, Richmond, VA, USA.

Journal of molecular and cellular cardiology
|November 20, 2025
PubMed
概括

斯芬哥辛-1-酸盐 (S1P) 激活心肌细胞中胀激活的化物电流 (ICl,swell). 这种激活是由线粒体产生的活性氧物种 (ROS) 介导的,而不是NADPH氧化酶2 (NOX2).

关键词:
心脏肌细胞是心脏肌细胞.线粒体中的线粒体.有反应性氧物种的反应性氧物种.斯芬戈辛-1-酸盐是一种酸盐.量敏感的化物电流对体积敏感.

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