相关实验视频

Updated: Jan 10, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

在Clostridioides difficile感染中实现更好的严重程度分层:弥合监测和临床实践之间的差距

Niamh Reidy¹, Jack H Casey¹, Mairead Skally²

¹Department of Clinical Microbiology, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

The Journal of hospital infection

|November 20, 2025

概括

严格的Clostridioides difficile感染 (sCDI) 的准确记录至关重要. 目前的监测标准可能低估了sCDI,而基于治疗的定义可能高估了它,因此需要修订定义以改善患者护理和资源配置.

科学领域:

传染性疾病传染性疾病
临床微生物学临床微生物学
医疗卫生流行病学医疗卫生流行病学

背景情况:

准确识别严重的Clostridioides difficile感染 (sCDI) 对患者管理和资源分配至关重要.
现有的监测和基于治疗的sCDI定义在应用和准确性方面有所不同.
为了一致的风险分层和临床决策,需要标准化的sCDI病例定义.

研究的目的:

为了比较国家监测标准与欧洲临床微生物学和传染病学会 (ESCMID) 基于治疗的定义来识别严重的Clostridioides difficile感染 (sCDI) 的实用性.
在现实临床环境中评估当前sCDI定义的准确性.
确定在sCDI分类和病例检测方面需要改进的领域.

主要方法:

在爱尔兰一家三级医院一年内对140例Clostridioides difficile感染 (CDI) 病例进行了回顾性审查.
使用爱尔兰国家监测标准和ESCMID基于sCDI和严重复杂CDI (sc-CDI) 的治疗标准对CDI发作进行分类.
对患者人口统计学,抗菌剂暴露,核核型,序列类型,放射学和临床结果的分析.

主要成果:

只有1.4%的CDI发作符合sCDI的国家监测标准.
相比之下,45%的人符合ESCMID的sCDI标准,13.5%的人符合ESCMID严重并发症CDI (sc-CDI) 标准.
序列类型ST11和ST10与更严重的病例有关,并且在ESCMID定义的严重病例中,很大一部分只符合一个标准,表明潜在的高估.

结论:

国家监测定义可能低估了严重Clostridioides difficile感染 (sCDI) 的负担.
基于ESCMID治疗的定义可能会高估sCDI,可能导致资源分配不适当.
需要修订,临床平衡的sCDI定义,以改善严重程度分层,病例检测和医疗保健资源管理.

关键词:

CDI流行病学CDI流行病学案例定义案例定义困难的闭膜瘤,CDI.严重的CDI是严重的CDI.

更多相关视频

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 14, 2013

相关概念视频

Principles of Disease Surveillance

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...

Healthcare Associated Infections II: Preventive Measures

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...

Transmission-based Precautions I: Contact, Enteric, and Droplets

Transmission-based Precautions I: Contact, Enteric, and Droplets

Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...