来自烟花相关气溶的全挥发性有机化合物的毒性作用和作用途径
Mingqi Liu1, Yaoqiang Huo1, Uudam Hu1
1Key Laboratory of Environmental Pollution Control and Remediation at Universities of Inner Mongolia Autonomous Region, College of Resources and Environmental Engineering, Inner Mongolia University of Technology, Hohhot, 010051, China.
Environmental pollution (Barking, Essex : 1987)
|November 20, 2025
概括
烟花释放有害有机化合物,通过各种毒性途径影响人类健康. 这项研究分析了烟花喷雾剂,以了解这些风险及其细胞机制.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 大气科学 大气科学
背景情况:
- 烟花在很大程度上会将有机化合物释放到大气中.
- 这些化合物的特定毒性作用和人类暴露途径尚不清楚.
- 全挥发性有机化合物 (FVOC) 是烟花喷雾剂的关键组成部分.
研究的目的:
- 为了确定烟花相关气溶中的FVOCs的化学指纹.
- 使用Tox21通路数据集评估这些有机化合物与毒性影响之间的关联.
- 阐明烟花产生的FVOCs影响人类细胞的机制.
主要方法:
- 在烟花活动期间分析FVOC度和毒性等效量 (TEQ).
- 对有助于整体毒性的关键有机化合物的选.
- 确定有机化合物,特定的毒性作用和细胞信号通路 (例如,雄激素受体,雌激素受体) 之间的相关性分析.
主要成果:
- 与非烟花活动期间相比,烟花活动期间的FVOC和TEQ水平明显高于非烟花活动期间.
- 半挥发性有机化合物 (SVOC) 是FVOC度和TEQ的主要贡献者.
- 确定的主要毒性影响包括眼睛刺激,皮肤敏感化,呼吸系统问题和细胞毒性,主要与,酒精和环碳化合物有关.
结论:
- 烟花产生的FVOC对人类健康构成重大毒性风险.
- 这些化合物通过调节关键的细胞信号通路,包括与激素受体和线粒体功能相关的信号通路来施加毒性.
- 这项研究为特定有机气溶分子与不良健康结果之间的联系提供了新的见解.
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