弥合差距:解决NACC在UDS版本中不断发展的认知电池问题
Michael L Lee1, Seo-Eun Choi1, Shubhabrata Mukherjee1
1Department of Medicine, University of Washington, Seattle, Washington, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|November 20, 2025
概括
同校准的认知分数协调了统一数据集 (UDS) 版本中的数据,验证了内存,执行功能和语言性能. 这些协调得分现在可用于阿尔茨海默氏症研究.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 生物统计学 生物统计学
背景情况:
- 统一数据集 (UDS) 神经心理学电池在第3版中进行了更新,取代了UDS 1和2中的旧测试.
- 这种过渡需要在不同的UDS版本中验证认知领域得分,以确保数据连续性.
研究的目的:
- 为了验证在UDS版本中对记忆,执行功能和语言的共同校准和协调的认知领域得分.
- 为了评估这些得分的可靠性,使用过路样本,神经成像数据和APOE基因型.
主要方法:
- 对49,396名参与者的认知领域得分进行了联合校准和协调.
- 在一个行人交叉口样本中,与传统的 equipercentile 等等比的同校准得分进行比较 (n=955).
- 通过与磁共振成像 (MRI) 发现 (n=2458) 和APOE基因型 (n=27,857) 的关联来验证域得分.
主要成果:
- 联合校准包括约25%的参与者,数据涵盖UDS 1&2和UDS 3.
- 在UDS 1&2和UDS 3域分数和等效分数之间的相关性是可比的.
- 协调得分显示了与神经成像和APOE基因型的显著关联,并揭示了跨UDS时代的认知性能差异.
结论:
- 纵向同校准和协调的认知域得分有效地弥合了UDS版本之间的数据差距.
- 这些经过验证的分数可以通过国家阿尔茨海默氏症协调中心 (NACC) 进行阿尔茨海默氏症研究.
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