美国西班牙裔/拉丁裔成年人宿主遗传,肠道微生物群和喘之间的关系
Maggie A Stanislawski1, Elizabeth Litkowski2,3, Christopher H Arehart4,5,6
1Department of Biomedical Informatics, School of Medicine, University of Colorado Anschutz, Aurora, CO, USA. maggie.stanislawski@cuanschutz.edu.
Nature communications
|November 20, 2025
概括
肠道微生物组合与西班牙裔/拉丁裔成年人的喘有关,独立于肥胖. 微生物数据改善了除了遗传学和风险因素之外的喘预测,突出了它在喘病理生理学中的作用.
科学领域:
- 微生物组研究的研究.
- 遗传流行病学遗传流行病学
- 公共卫生 公共卫生
背景情况:
- 喘是一种复杂的呼吸系统疾病,经常与肥胖同时发生.
- 了解肠道微生物组在喘病理生理学中的作用对于开发新的干预措施至关重要.
- 西班牙裔/拉丁裔成年人代表了一个多元化的人口,具有与喘和肥胖有关的独特健康状况.
研究的目的:
- 研究美国西班牙裔/拉丁裔成年人肠道微生物特征与喘之间的关联.
- 为了确定肥胖状态是否会改变肠道微生物群和喘之间的关系.
- 与宿主遗传学相比,评估微生物因素对喘状况的预测价值.
主要方法:
- 利用了来自西班牙裔社区健康研究/拉丁裔研究的全基因组测序和猎枪元基因组数据.
- 评估了阿尔法多样性,β多样性和分类丰度与喘的横截面关联,考虑到肥胖状态 (BMI ≥30 kg/m2).
- 生成了喘多原风险评分 (PRS),并比较了遗传和微生物数据的分类准确性.
主要成果:
- 喘与肠道微生物分类组合的显著差异有关 (β多样性;p=0.001),独立于肥胖 (p=0.31).
- 喘和α多样性 (p>0.17) 之间没有发现显著的关联,尽管肥胖与较低的α多样性 (p<0.01) 有关.
- 与基线风险因素和喘PRS (p=0.04) 的模型相比,微生物信息提高了喘分类的准确性,其中特定的种群如Lactobacillus和Enterococcus表现出改变的丰度.
结论:
- 肠道微生物群的组成与西班牙裔/拉丁裔成年人的喘有关,无论肥胖程度如何.
- 微生物签名为喘病理生理学提供了宝贵的见解,并可以改善喘预测.
- 针对性喘管理策略需要对宿主微生物相互作用进行进一步的研究.
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