相关实验视频

Updated: Jan 10, 2026

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.6K

细胞系匹配的参考可以实现高精度的功能基因组学

Luca Corda1, Emilia Volpe1, Hamza Dallali1

  • 1Giunta Laboratory of Genome Evolution, Department of Biology and Biotechnologies Charles Darwin, University of Rome "Sapienza", Piazzale Aldo Moro 5, Rome, 00185, Italy.

Nature communications
|November 20, 2025
PubMed
概括

使用特定于细胞系的匹配参考基因组,如RPE-1,大大提高了基因组,表观基因组和转录基因组分析和基因组编辑的准确性,特别是在中间体.

更多相关视频

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

12.2K
HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

8.7K

相关概念视频

Cell Lines01:16

Cell Lines

A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...
10.0K