整合性聚焦太空曝光体-整合体:生理学挑战和低地球轨道之外的对策的实际限制
Damian M Bailey1, Dieter Blottner2,3, Hanns-Christian Gunga4
1Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Glamorgan, UK. damian.bailey@southwales.ac.uk.
宇航员面临着太空旅行带来的健康风险. 了解太空曝光体-整体体相互作用可以帮助个性化反制措施,以实现更安全的深空探索.
科学领域:
- 太空探索 太空探索
- 宇航员的健康状况
- 暴露体-整体体相互作用
背景情况:
- 人类太空飞行正在向可持续探索迈进,像NASA的阿特米斯计划这样的任务针对月球和火星的目的地.
- 执行这些任务的宇航员面临重大危险,包括重力变化,隔离和宇宙辐射.
- 这些危害与30多种不同的健康风险有关,对长期太空任务构成挑战.
研究的目的:
- 审查当前对空间暴露体-整体体相互作用的理解.
- 概述如何利用这种理解来改善宇航员风险分层.
- 确定针对个性化对策的策略,并解决安全深空探索的知识差距.
主要方法:
- 本综述综合了欧洲航天局 (ESA) 社区的专业知识.
- 它的重点是空间暴露和人类基因组之间的相互作用.
- 该审查确定了未来研究和对策开发的关键领域.
主要成果:
- 了解太空暴露体-整体体相互作用对于宇航员健康至关重要.
- 这种知识可以为宇航员提供个性化的风险评估.
- 它指导着针对太空飞行引起的健康风险制定有针对性的对策.
结论:
- 基于exposome-integrome相互作用的个性化对策对于安全的深空探索至关重要.
- 解决目前的知识差距对于减轻宇航员健康风险至关重要.
- 这种方法支持推进可持续的人类太空飞行倡议.
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