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与巨细胞菌相关的基因预测肺腺癌的预后和治疗反应

TianRong Yang^1,2, Qin Liu^2,3, Wei Li^2,4

¹Department of Public Health and Hospital Infection Control, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, China.

Scientific reports

|November 20, 2025

概括

这项研究确定了关键基因,TUBB6和CAT,参与巨细胞线粒体自 (线粒体自) 预测肺腺癌 (LUAD) 患者的生存率. 一个新的风险模型显示,高风险患者的治疗结果较差,对某些化疗反应更好.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
免疫学免疫学免疫学

背景情况:

与瘤相关的巨细胞中的线粒体自性 (线粒体自性) 在肺腺癌 (LUAD) 瘤微环境中至关重要,但仍然不太了解.
识别调节巨细胞中线粒细胞的关键基因可以提高预后准确性和LUAD的治疗策略.

研究的目的:

在LUAD瘤微环境中识别关键的巨细胞菌相关基因.
基于这些基因,开发和验证基于这些基因的LUAD患者强大的预后模型.

主要方法:

集成的单细胞转录组数据与机器学习算法 (LASSO,SVM,随机森林).
使用已识别的预后基因构建并验证了一种新的风险评分模型.
进行了体外实验,以验证LUAD细胞行为中的基因功能.

主要成果:

确定TUBB6和CAT作为LUAD的核心预后基因.
开发了一个风险模型 (RiskScore = 0.225 × TUBB6 - 0.19 × CAT),与整体存活率 (P < 0.001) 有显著的相关性.
高风险得分表明免疫微环境变化和对西斯丁和凝胺的敏感性增加;巨细胞TUBB6的过度表达促进了LUAD细胞的生长和转移.

结论:

建立了一个可靠的预后模型,基于巨细胞化的LUAD.
突出了TUBB6和CAT作为新的生物标志物和LUAD精准医学的潜在治疗点.

关键词:

药物敏感性药物敏感性肺部腺癌是肺部的癌症.机器学习是机器学习.巨细胞是一个巨细胞.线粒细胞衰变 (mitophagy) 是一种细胞衰变的过程.单细胞转录组学单细胞转录组学

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