升高的FDP水平独立预测HBV-ACLF患者治疗人工肝支持系统治疗的不良结果
Xu Yang1, Xiaoqi Zhou1, Dachuan Cai1
1Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Scientific reports
|November 20, 2025
概括
纤维素降解产物 (FDP) 水平升高表明,B型肝炎病毒相关的急性至慢性肝功能衰竭 (HBV-ACLF) 患者的28天死亡风险较高. 然而,强化人工肝支持疗法可能会改善这些高风险患者的生存结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
- 生物化学 生物化学
背景情况:
- 急性慢性肝衰竭 (ACLF) 是一种严重的疾病,其特征是全身炎症和凝血异常.
- 纤维素降解产物 (FDP) 是纤维素分解的关键标记物,反映了身体的血液凝结和分解过程.
研究的目的:
- 调查乙肝病毒相关ACLF (HBV-ACLF) 患者纤维素降解产品 (FDP) 水平和28天死亡率之间的关联.
- 评估FDP对接受人工肝支持系统 (ALSS) 治疗的HBV-ACLF患者死亡率的预测值.
主要方法:
- 对接受ALSS治疗的520名HBV-ACLF患者的回顾性分析.
- 考克斯回归分析以确定FDP水平与28天死亡率之间的关系.
- 接收机操作特征 (ROC) 曲线分析,以评估FDP的预测准确性.
主要成果:
- 28天的死亡率为20.2%. 较高的FDP水平与28天死亡率的增加显著相关 (P < 0.001).
- 每增加10μg/mL的FDP与死亡风险上升12.8%相关 (HR = 1.128).
- 高水平的FDP (≥11.1μg/mL) 与低水平相比,增加了3.222倍的死亡风险 (P<0.001).
结论:
- 升高的FDP水平是HBV-ACLF患者28天死亡率的重要预测因素.
- 多次ALSS治疗可能会减轻高FDP水平的HBV-ACLF患者的死亡风险.
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