在精密瘤学中以人工智能驱动的多学科整合:将数据洪水与临床决策相连接起来
Chou-Yi Hsu1, Shavan Askar2,3, Samer Saleem Alshkarchy4
1Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, 71710, Taiwan.
Clinical and experimental medicine
|November 20, 2025
概括
人工智能 (AI) 整合了用于癌症研究的多学科数据,改善了早期检测和个性化治疗. 这种方法结合了基因组学,蛋白质组学和放射学,以实现更准确的诊断和预后.
科学领域:
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
- 人工智能的人工智能
背景情况:
- 癌症表现出显著的分子异质性,挑战了传统的单一omics方法.
- 整合多omics数据 (基因组学,转录组学,蛋白质组学,代谢组学,放射组学) 可以提高诊断和预后的准确性.
- 当前的方法与多主题数据集成的复杂性和规模作斗争.
研究的目的:
- 审查人工智能 (AI) 如何实现可扩展,非线性整合多学科数据以获得临床见解.
- 探索尖端的人工智能方法及其在精密瘤学中的应用.
- 解决人工智能驱动的癌症管理中的翻译挑战和新兴趋势.
主要方法:
- 审查人工智能 (AI) 方法,包括深度学习和机器学习.
- 探索特定的人工智能技术:图形神经网络,变压器和可解释的人工智能 (XAI).
- 综合应用在治疗选择,早期检测和诊断中的应用.
主要成果:
- 人工智能分类器在早期癌症检测方面达到0.81-0.87的AUC.
- 人工智能使不同层次的omics层的非线性整合成为可操作的见解.
- 人工智能应用在预测治疗耐药性和实现非侵入性诊断方面表现有前途.
结论:
- 以人工智能为动力的多omics集成对于克服癌症异质性至关重要.
- 新兴的趋势,如联合学习和空间奥米克,标志着向个性化癌症护理的转变.
- 尽管面临挑战,但人工智能整合有望将瘤学转变为积极主动的,个性化的患者管理.
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