相关实验视频

Updated: Jan 10, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

在偏头痛模型中,益生菌通过肠-大脑-三轴调节中央和外周敏感化

Phichaya Suthivanich¹, Sirikorn Vongseenin², Vichaya Auvichayapat²

¹Interdisciplinary Program of Physiology, Faculty of Graduate School, Chulalongkorn University, Bangkok, Thailand.

Scientific reports

|November 20, 2025

概括

特定的益生菌通过平静大脑和神经活动,显著减少了偏头痛触发因素. 这些发现支持针对性肠-大脑轴治疗来预防偏头痛.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
胃肠病学胃肠病学

背景情况:

肠-大脑轴在偏头痛病理生理学中起着至关重要的作用.
皮层扩散抑郁症 (CSD) 是偏头痛的一个关键事件.
益生菌可以调节肠-大脑轴,并影响神经疾病.

研究的目的:

在大鼠模型中研究特定益生菌菌株对CSD的神经生理学影响.
评估 Lactobacillus plantarum 和 Bifidobacterium longum 对神经元激发性在三系统中的影响.

主要方法:

在老鼠身上,使用了涉及CSD的偏头痛模型.
不同的益生菌配方 (L. plantarum,B. longum,组合,多菌株) 被使用.
记录了神经生理学参数,包括CSD频率/幅度和三角结节 (TG) 神经元活动.

主要成果:

B. longum显著减少了中央证券交易所的频率.
L. plantarum及其与B. longum的组合减弱了CSD振幅,表明皮质过敏性降低了.
益生菌降低了TG神经元尖峰数量和超极化的静止膜潜力,这表明外周无敏化和神经元刺激性降低.
B. longum 独特延长的动作潜力的持续时间和脱极化时间.

结论:

菌株特定的益生菌调节肠-大脑-三角轴.
有针对性的益生菌补充可以抑制与偏头痛相关的中央和外周敏感化机制.
这些发现支持开发基于微生物群的非药物偏头痛预防.

关键词:

皮层扩散抑郁症是皮层扩散的抑郁症.肠大脑轴肠大脑轴偏头痛是一种偏头痛.神经元刺激性的神经元刺激性益生菌疗法是一种益生菌疗法.三胞胎节的三胞胎节.

更多相关视频

In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments

In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments

Published on: October 25, 2016

In vitro Functional Characterization of Mouse Colorectal Afferent Endings

In vitro Functional Characterization of Mouse Colorectal Afferent Endings

Published on: January 21, 2015

相关概念视频

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Pathophysiology of Vomiting

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...