相关实验视频
Updated: Jan 10, 2026

10:37
Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
36.4K
与宫癌进展中的上皮介质过渡 (EMT) 相关的基因
Kiran Kumari1, Raviranjan Kumar Gupta1, Saket Kumar2
1Cancer Genomics and Therapeutics Laboratory, Department of Zoology, School of Life Sciences, Mahatma Gandhi Central University Bihar (MGCUB), Motihari, 845401, India.
Discover oncology
|November 20, 2025
概括
这项研究确定了8个关键基因,这些基因与宫癌中的上皮-介质细胞转换 (EMT) 有关. CDH2和FN1显示出预后价值,表明早期诊断和改善患者结果的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 子宫癌仍然是一个重大的全球健康挑战,由于不明确的分子进展机制,经常在晚期被诊断出来.
- 表皮-介质细胞过渡 (EMT) 在癌症进展和转移中至关重要,突出显示了早期诊断生物标志物的需要.
研究的目的:
- 确定与宫癌EMT相关的常见差异表达基因 (DEGs).
- 发现用于宫癌进展的新型早期诊断和预后生物标志物.
主要方法:
- 使用的基因表达综合 (GEO) 数据集 (GSE26511,GSE67522,GSE9750) 用于DEG分析.
- 进行了基因本体学 (GO),KEGG通路丰富和蛋白质-蛋白质相互作用 (PPI) 分析.
- 使用分子相互作用网络识别了枢纽基因,并通过生存分析评估了它们的预后意义.
主要成果:
- 在三个数据集中确定了11,339个重叠的DEG.
- 确定了八个枢纽基因 (CDH1,CDH2,MMP2,CD44,FN1,FGF2,SNAI1,SNAI2),这些基因与EMT关键相关.
- CDH2 (N-cadherin) 与整体存活率有显著的相关性,而FN1 (纤维菌素) 与无病存活率有显著的相关性.
结论:
- 已识别的八个枢纽基因对宫癌的EMT进展具有潜在意义.
- CDH2和FN1具有显著的预后价值,支持它们作为诊断生物标志物的作用.
- 这些基因为早期检测和改善宫癌管理策略提供了潜力.
相关概念视频
Metastasis
6.3K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.3K
Cadherins in Tissue Organization
3.8K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
3.8K
Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
Mitogens and the Cell Cycle
7.7K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.7K
Cancer-Critical Genes II: Tumor Suppressor Genes
9.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.3K
Induced Pluripotent Stem Cells
5.4K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
5.4K

