刺激性肠综合征患者的肠道微生物功能途径发生变化,使得能够精确地了解健康状况
Eric Patridge1, Anmol Gorakshakar1, Matthew M Molusky1
1Viome Research Institute, Viome Life Sciences Inc, New York City, NY, USA.
BMC gastroenterology
|November 21, 2025
概括
新的肠道微生物群路径得分可以早期识别易怒肠综合征 (IBS) 风险. 这些分子标记物为肠道健康提供了洞察力,并为功能性胃肠道疾病提供了潜在的干预措施.
科学领域:
- 微生物组研究的研究.
- 转录基因组学 (Metatranscriptomics) 是一种关于转录基因组学的研究.
- 功能性基因组学是一种功能性基因组学.
背景情况:
- 功能性胃肠道疾病 (FGIDs) 带来了诊断和治疗方面的挑战.
- 对于早期的健康见解和干预FGIDs的分子标记物有着至关重要的需求.
- 这项研究使用来自大量成年人群 (n=80,570) 的便基转录基因组数据检查肠道微生物组活动,以刺激性肠道综合征 (IBS) 为模型.
研究的目的:
- 开发和验证从肠道转录基因组数据中获得的功能途径得分.
- 评估这些分数与IBS及其亚型的存在之间的关联.
- 探索这些分数在早期健康洞察和胃肠道疾病干预方面的潜力.
主要方法:
- 开发了八个肠道微生物功能通路得分基于KEGG正义学.
- 在一个子群体 (n=9,350) 中使用规范方法定义了"好"和"不最佳"路径活动.
- 在一个独立的队列 (n=71,220) 中,通过使用诊断问卷和自我报告的表型,验证了"非最佳"分数与IBS及其亚型的关联.
主要成果:
- "非最佳"功能途径得分与IBS及其亚型 (IBS-便秘,IBS-腹,IBS-混合型) 的几率增加显著相关.
- 这些发现在不同IBS分类和评估方法 (罗马IV标准,自我报告的表型) 中是一致的.
- 这证明了基于转录基因的途径得分在识别易患IBS风险较高的个体中的实用性.
结论:
- 功能性通路得分提供了对可能导致IBS的分子通路的早期健康见解,超越了基于症状的诊断.
- 这些分子终点可以帮助评估干预的有效性,开发预测算法,并个性化营养和胃肠道疾病的治疗.
- 该研究强调了肠道转录代码学在功能性胃肠道疾病的诊断和治疗方面的潜力.
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