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克里斯合晶:预测,制备,表征,以及在体外/在生物体内评估

Baoxi Zhang1, Yifei Xie1, Weiwen Ji1

  • 1Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Molecular pharmaceutics
|November 21, 2025
PubMed
概括

晶体工程改善了素 (CHR) 的溶解性和可用性. 该CHR-SOP共晶体显示显著增强的溶解性和溶解率,标记它为进一步制药研究的有希望的候选人.

关键词:
克里斯林 (chrysin) 是一种的物质.协同晶体 协同晶体 是一个改善了药物治疗能力.查检查 查检查 查检查 查检查

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In pharmaceutical development, it's crucial to establish a predictive in vitro–in vivo correlation (IVIVC) for two or more formulations to gain a comprehensive understanding of release properties. IVIVC reduces the need for costly in vivo studies and facilitates the establishment of meaningful dissolution specifications with significant cost savings and decreased regulatory burden. Furthermore, a meaningful IVIVC should predict Cmax and AUC within 20%, aligning with FDA guidance while...
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