相关实验视频
Updated: Jan 10, 2026

05:03
Author Spotlight: Effective Rapid Blood Perfusion in Xenopus
Published on: May 16, 2023
5.4K
青的高海拔适应 (案例研究:Nanorana parkeri):从生理现象型到海拔奥米克
Xuejing Zhang1, Yonggang Niu2, Shengkang Men1
1School of Life Sciences, Lanzhou University, Lanzhou, China.
Integrative zoology
|November 21, 2025
概括
西高原青通过降低新陈代谢率和调整蛋白质表达来在极高处生存. 这种节能和细胞保护策略有助于在恶劣的低氧环境中生存.
科学领域:
- 动物学 动物学
- 生理学 生理学 生理学
- 生物化学 生物化学
背景情况:
- 高海拔对动物生活构成重大生理挑战.
- 西高原青 (Nanorana parkeri) 是研究适应高海拔环境的理想模型.
- 这种物种是青海 - 西藏高原的特有物种,生活在2800至5100米之间.
研究的目的:
- 为了比较高 (4600米) 和低 (3400米) 高度息地之间的环境条件.
- 描述高海拔青的生理特征.
- 使用代谢和蛋白质组数据阐明适应极端环境的机制.
主要方法:
- 收集环境数据 (温度,溶解氧).
- 从不同高度对青的生理特征分析.
- 代谢和蛋白质组数据分析的整合.
主要成果:
- 高海拔息地具有较低的温度和溶解氧气.
- 高海拔的青表现出降低的新陈代谢率,降低的葡萄糖和β-酸,以及较低的酶活动.
- 观察到肝脏葡萄糖和酸盐的增加,糖脂代谢的改变,以及与压力/代谢相关的蛋白质 (例如GPX4) 的变化.
结论:
- 纳诺拉纳帕克里采用了代谢抑郁和蛋白质调整的协同策略,以实现高海拔生存.
- 这涉及优化能源效率和增强细胞保护机制.
- 这些发现提供了对外热脊椎动物适应极端环境的见解.
相关概念视频
Positive and Negative Feedback Loops
24.1K
Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires maintaining an internal dynamic equilibrium:
24.1K
Background and Environment Affect Phenotype
7.4K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
7.4K
Natural Selection and Adaptation
1.2K
Natural selection, a fundamental concept in evolutionary biology, is the mechanism by which evolution is driven, favoring organisms that are best adapted to their environments. This process enhances their chances of survival and reproduction. Adaptation, a key outcome of this process, involves genetic modifications that optimize an organism's functionality under specific environmental challenges, such as extreme cold or thinner air at high altitudes.
Beyond physical adaptations,...
Beyond physical adaptations,...
1.2K
Responses to Salt Stress
14.4K
Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.4K

