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Updated: Jan 10, 2026

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
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Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

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没有自我焚烧间隔器的抗体-药物联合体表现出强大的抗瘤活性

Victor T Ojo1, Nicholas A Bianchi1, Michele Z Yi1

  • 1School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States.

Journal of medicinal chemistry
|November 21, 2025
PubMed
概括

新的抗体-药物联合体 (ADC) 使用一种新的豆类可切割连接器来释放强效的拓酶-I抑制剂 (TOP1i),而无需间隔器. 这些TOP1iADC在胰腺癌模型中显示出强烈的疗效.

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